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A thank you and some science updates
Dear supporters,

It has been some time since we sent you a science post, not because we haven't been busy, quite the contrary.

But before sharing exciting science, we'd like to express our deep gratitude for your continued support and computational time.

Thank you!

We had a busy few years working on important topics in malaria research and global health: from vector control strategies in pre-elimination countries, to optimization of malaria control tools in support of the Global Fund applications, to key analyses for policy decisions on malaria vaccines. Just to name a few.

Here are some recent articles we would like to share with you:

Malaria Vaccines:
You may have read recently in the news that the world may be close to the first malaria vaccine being approved for use in sub-Saharan Africa. The European Medicines Agency (EMA) adopted a positive scientific opinion for the malaria vaccine RTS,S, also known as Mosquirix, in children aged 6 weeks to 17 months. This is a key step in the regulatory process towards making RTS,S available for the population at risk of malaria in sub-Saharan Africa. The next step involves WHO reviewing the evidence base for RTS,S and making a policy recommendation for if and how this vaccine should be used alongside other tools to prevent malaria in different endemic settings. The policy recommendation is meant to provide technical guidance to endemic countries considering the vaccine introduction. The WHO has indicated that such a policy recommendation may be possible still in 2015.

The modelling team and your work contributed to assessment of the vaccine in terms of its expected public health impact and cost- effectiveness, providing information in addition to the clinical trial data.

Some of this work was recently published
"The public health impact of malaria vaccine RTS,S in malaria endemic Africa: country-specific predictions using 18 month follow-up Phase III data and simulation models"
by Melissa Penny and our team at Swiss TPH

You can access the article here:

Thanks for your help!

Malaria Dynamics
We also recently published on another important issue: reasons for potential shift of burden to older ages with partially effective malarial interventions. Simulations from OpenMalaria were used to address this, so we thank you for your support.

"Age-shifting in malaria incidence as a result of induced immunological deficit: a simulation study"
by Peter Pemberton-Ross in our modelling team at Swiss TPH

You can access the article here:

Cost Effectiveness of Malaria Control Interventions

Tools that allow for in silico optimization of available malaria control strategies can assist decision-making process for prioritizing interventions.

One such example :
"Modeling the Cost Effectiveness of Malaria Control Interventions in the Highlands of Western Kenya"
by Erin Stuckey previously with our modelling team at Swiss TPH

you can access the article here:

Again thank you for your continued support and volunteering computer time!

Best regards,
Melissa Penny and the malaria modelling team at Swiss Tropical and Public Health Institute.
22 Sep 2015 13:51:06 UTC · Comment

OpenMalaria v33 on beta
Dear users,

We have just updated the Beta application on to version 33 of our simulation software, OpenMalaria. At the same time we have started some new jobs to take advantage of the features in this version of the software.

Since several users reported problems with the 64-bit Windows version of the app added in the last Beta update, this has been disabled and we have reverted to using the 32-bit version on 64-bit Windows.

- team
17 Dec 2014 11:20:35 UTC · Comment

OpenMalaria looking for a new systems administrator/software engineer
The team that developed the OpenMalaria software that runs on is looking for a new systems administrator/software engineer to work in Basel, Switzerland. For details see:
3 Sep 2014 10:25:09 UTC · Comment

Updating test application
Dear users,

As of today, I am updating the malaria control test application to OpenMalaria v32 (see previous news item). Also today, I will be starting a small experiment using this simulator version of roughly 17000 workunits.

With this release comes support for an extra platform: 64-bit Windows (previously, the 32-bit Windows application was used on both 32-bit and 64-bit Windows). This build requires the .NET framework and has so far only been tested on Windows 7 and 8.1, so let us know if you run into any issues.

- D Hardy
18 Jul 2014 9:02:47 UTC · Comment

Dear users,

I am scheduling a small amount of down-time next Monday for server updates. If all goes to plan this will only be a few minutes.

In other news, release 32 of our simulator software, OpenMalaria, is ready for use. This release includes a lot of work to increase the breadth of types of malaria intervention and intervention deployment strategies which OpenMalaria can simulate, as well as allowing monitoring of multiple subsets of the simulated human population. The test application and shortly thereafter branch A will be updated to use this in the next few weeks.


Diggory Hardy
30 Jun 2014 14:41:03 UTC · Comment

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